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TGF-β and BMPs, that are members of the TGF-β superfamily, also initiate pathways that are highly relevant in maintaining stem cell self-renewal [42], [88].
Asymptomatic HEV shedding in vaccine recipients, shown previously in primates, may be relevant in maintaining the environmental reservoir of HEV for human infection.
Furthermore, recent studies have shown that some sHSPs localize to the mammalian and plant ER, in which sHSPs would play protective effects, being indeed relevant in maintaining ER homeostasis [ 134].
The HSP90 co-chaperone cdc37 ranked the highest in a genome-wide functional screen on two KIT-mutant cell lines, suggesting that the chaperones are relevant in maintaining KIT signaling [ 68].
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There is increasing evidence that estrogens fulfill a relevant role in maintaining the homeostasis of articular tissues and, hence, of the joint itself.
Furthermore, we can use structural properties of the network to prioritize genes for further analysis that are likely to play functionally relevant roles in maintaining network integrity and controlling information flow throughout the system.
Of note, it has been recently shown that the key regulator of aerobic glycolysis PKM2 has a relevant role in maintaining cellular redox homeostasis allowing greater diversion of glycolytic intermediates into pentose phosphate pathway and NADPH biosynthesis in response to oxidative stress.
Chromosomal proteins determining the chromatin state, such as nuclear membrane (Capelson et al. 2010; Vaquerizas et al. 2010), insulators (Maeda and Karch 2007; Wallace et al. 2009; Negre et al. 2010), and chromatin remodeling (Kalmykova et al. 2005; Li and Reinberg 2011) proteins, may therefore play a relevant role in maintaining gene clusters.
In terms of substance misuse practice, the findings should assist relevant policy makers in maintaining a healthy workforce.
A growing body of evidence suggests that basal autophagy has a relevant homeostatic role in maintaining protein and organelle quality control, acting in parallel with the UPS to prevent accumulation of poly-ubiquitinated and aggregated proteins.
Our results show asymmetry in relation to the incidental codification of color, similar to the asymmetry in the incidental conjunction of location in the work of Olson and Marshuetz (2005 This asymmetry indicates the existence of a hierarchy in maintaining relevant objects in our memory that are also related to memorized objects and not just between stores (Ecker et al. 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com