Although we do not suggest S BET as a "universal" dose metric (chemistry, charge, etc., are also relevant), we conclude that for the dose metric examined here, S BET is the most relevant dose parameter.
However, it is unlikely that these properties are relevant for the present study because the dose of rolipram that was used to enhance remyelination in the present study (0.5 mg/kg/day) is much lower than the dose at which rolipram is effective as an anti-inflammatory agent (3 mg/kg/day) up to 10 mg/kg) (Buttini et al, 1997; Francischi et al, 2000; Laemont et al, 1999).
Schneider et al. [13] did not specify which factors related to the test environment that should be evaluated and only consider it relevant for repeated dose toxicity studies.
Altered expression of genes involved in metabolic and signaling pathways and functions of the organism occurs after perinatal exposure of rat offspring to BDE-47 at doses relevant for the general population.
In further support of an association between MECP2 and aggression, impulse control alterations in individuals with MECP2/Mecp2 gene duplication syndrome have been reported (Ramocki et al, 2009), even though the findings of the present study are more relevant for the understanding of physiological gene-dose effects on social behavior.
The therapy studies identified as "clinically relevant" for the evaluation of drugs and fixed-dose combinations thereof were rated on the one hand in terms of "study quality" (this comprises among other criteria the methodology, design, and internal and external validity), and on the other hand in terms of the "scientific evidence", i.e. the degree of proven effect (efficacy).
This dose reduction is relevant for the clinical setting as there is a concern of increased side effects when both treatment modalities are combined, in particular with regard to bowel perforations and hemorragic events 17, 43, 49.
In spite of control theory where control signals are randomly generated, random generation would not be clinically relevant for medication doses and thus we designed the following approach.
In contrast, for tacrolimus genetic factors were relevant for individualized dosing, whereas body weight appeared irrelevant [ 37].
CsA displays relatively low inter-individual variability, at least compared with tacrolimus, in which genetic markers have been shown to be relevant for individualized dosing [ 18, 37].
