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Our findings concerning co-localization of β-catenin and GS suggests that the mechanism of post differentiation patterning recently hypothesized for liver tissue [31] may likewise be relevant for skin.
However, such conditions are not necessarily relevant for skin or environmental exposure.
A detailed list of variables relevant for skin cancer was provided and, for each available variable in the list, the authors were required to compile a form with a clear and complete description on how it was collected and coded.
The fact that insulin is biologically relevant for skin cells derives from the observation that insulin is an essential component for cultured human keratinocytes, demonstrating its involvement in the regulation of proliferation, survival, and metabolism [ 114].
In the present study, neutralization validation by chemical inhibition using an alcoholic solution containing 2% CHG was carried out using 5 bacterial species relevant for skin antisepsis and which were, with the exception of Staphylococcus aureus, not part of the EN.
For example, it has been demonstrated that UV radiation, especially UVA, cause mutations of the tumor suppressor p53 gene in the basal layers of the epidermis, a region that contains keratinocyte stem cells and thus may be particularly relevant for skin carcinogenesis.
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We found the senescence marker p16INK4a significantly increased in mutant SOD2-deficient skin, and this is particularly relevant for human skin aging as we and others have previously shown that reactive oxygen species accumulate fibroblasts in skin in vitro and in vivo and, importantly, p16INK4a increases in human skin with age and represents a robust in vivo marker for aging.
The optical properties are also highly relevant for, e.g., skin disease assessment [ 4– 6] and tumor/cancer characterization [ 7– 9].
These examples illustrate how age-related methylation changes can have relatively subtle, but significant expression changes on genes that are relevant for proper skin homeostasis.
Nonetheless, says Seagrave, "Air liquid interface exposures are clearly more physiologically relevant for lung and skin cells than conventional submersion culture systems".
However, the latter, may be less relevant for people with darker skin.
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