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We were able to obtain relevant estimates for models 1 and 2 for all twelve studies and for model 3 for eleven studies (Web Table 3).
Directly relevant estimates for the ICC were not available, however, published models associating the ICC and outcome prevalence for a range of outcomes in community and health services settings suggested an ICC between 0.01 and 0.05.
Figure 2A shows the relevant estimates for the East of England for (a typical annual cohort of 1296 cases) showing that 27 deaths (point estimate of 27.2 with 95% CI 25.2 to 29.2) can be postponed to a time point beyond 5 years from diagnosis.
We believe that the updated sample size estimation is based on as accurate variables as possible, with the same conservative value for α, a value of SD, which is based on the most updated empirical body of evidence, and relevant estimates for the expected MIREDIF and effect size.
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For these reasons, the attributable fractions in column 8 (based on non-smokers with a current partner who was ever a smoker) are taken as the relevant estimate for the UK population.
Moreover, there were no relevant estimates available for the proportion of patients provided assisted care or care in institutions such as nursing homes after non-fatal stroke or MI.
Relevant estimates were found for 14 chemicals or their groups or mixtures.
Thus, estimates based on EORTC20981 5-year data can be regarded as the most conservative, reliable, and clinically relevant estimates currently available for the purposes of this study in Finland and in other European settings.
We therefore recommend that applied investigators wanting to use a GMM or SMM approach should plot the relevant estimating function for a large range of values of the parameter of interest to check if there is a unique solution to the estimating equations.
Confidence intervals (CIs) (95%) were calculated for all relevant estimates using StatXact (version 5).
In all, 95% CIs were calculated for all relevant estimates using StatXact (version 5; Cytel, Cambridge, MA, USA).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com