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However, given a sufficiently large sample size, phenotypic variables can be screened on G × E when no explicit hypotheses exist on which measures of the environment will interact with genetic influences of the phenotype, or when the relevant environment measures are not available (e.g. an IQ datasets which lacks a measure of SES).
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Development of improved neighborhood environment measures that capture relevant geographic areas within complex communities and investigation of differences across urbanicity and sociodemographic composition are needed.
Such analyses have been carried out for some educationally relevant environments and school achievement measures [47], [48].
Developments in ecological momentary assessment (EMA) suggest the benefits of measuring symptoms at-the-moment in ecologically relevant environments [ 15].
Some care is required in determining what the relevant environments are.
Each conditioning environment measured 45×45×30 cm.
Participants Two patients, their close contacts, and relevant environments.
Concerning the measures of the environment, we were limited to measures obtained in TEDS which was itself limited by the fact that there are few measures of mathematics-relevant environments.
Although the strengths of our study included its use of a SNP set and its composite measure of mathematical ability, the study was limited in terms of its sample, its measures of mathematics-relevant environments and its power.
In the meantime, medical education is broadened with sociocultural perspectives, like situated learning and communities of practice, which may be relevant for measuring educational environment quality (Van der Zwet et al. 2011).
When the search for susceptibility genes is conducted using a design that includes relevant measures of the environment, this opens up the possibility of exploring gene−environment interaction (Rutter 2006).
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