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In addition, the potency of compounds against PDE10A could be optimized in itself, in order to achieve therapeutically relevant efficacy.
In conclusion, the results indicated a relevant efficacy of camptothecins against human prostate carcinoma models, in spite of p53 alterations.
Challenges in preclinical trials include identifying appropriate animal models, clinically relevant efficacy end points, and methods to monitor cardiovascular safety.
In this study of subjects with rapidly-escalating attacks of episodic migraine, treatment with DFN-11, a 3 mg SC sumatriptan autoinjector, was comparable to SC sumatriptan 6 mg on all clinically relevant efficacy endpoints.
However, none of them has shown clinically relevant efficacy [ 88].
Nonduplicated trials with relevant efficacy and safety information were selected (Supplementary Information Part III).
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The current treatments (except for joint replacement) have at best modest albeit clinically relevant efficacies, and are sometimes associated with substantial side effects or costs [ 17].
We will conduct meta-analyses to establish the effect of all reported therapies on patient-relevant efficacy and safety outcomes when possible.
These latter events rightfully belong in the safety or overall analysis, but are not relevant for efficacy, where they dilute real differences in efficacy with events unrelated to breast cancer.
Investigators should be encouraged to report meticulously and to use clinically relevant primary efficacy measures.
Environmentally generated pesticide photoproducts are relevant to efficacy and safety evaluations.
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