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Integration of these systems approaches will enable faster discovery and translation of clinically relevant drug combinations.
Over-expression of multidrug efflux pumps have been increasingly found to be associated with clinically relevant drug resistance.
Moreover, by blood sampling being performed the same morning as the neuropsychological testing, an accurate measure of the relevant drug level was obtained (Steen et al. 2015).
A better genotype phenotype correlation may help us to understand the mechanisms behind tumorigenesis as well as identify relevant drug targets.
Utilization and integration of these systems biology approaches hold great promise in speeding up the development of clinically relevant drug combinations.
Kinases represent one of the most important and therapeutically relevant drug target families involved in diseases like cancer and various other neurodegenerative, infectious and inflammatory diseases.
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Detailed understanding of their reaction pathway has been frustrated by the transient nature of this key intermediate and the absence of relevant drug-free structures.
In contrast to paclitaxel, STX2484 efficacy was unchanged in two clinically relevant drug-resistant models.
Here we solved a monomeric HCV p7 solution structure, yielding a relevant drug-binding hairpin conformation.
Clinically relevant drug-drug interactions as well as omissions of indicated medication affect more patients at discharge than at admission.
OTC medications are important in drug management, as they often cause clinically relevant drug-drug interactions or further DRPs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com