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Kathryn Arnold (University of York) found that long-term exposure to an environmentally relevant dosage of fluoxetine (Prozac), a commonly used antidepressant, altered physiology, behaviour and mass balance in starlings.
Animals in the AVP group received a continuous infusion of AVP at a clinically relevant dosage of 0.0001 IU/kg/minute (corresponding to 4 IU/h in a 70 kg critically ill patient [ 3, 12]) throughout the time of the experiment.
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For the analyses presented here, clinically relevant dosages of rosuvastatin and two other statins were compared over lifetime and 20-year time horizons.
Moreover, it remains to be precisely established if the oral administration of unsupplemented food is sufficient to gain clinically relevant dosages of bioactive compounds, if there is a preferred timing of the life when the addition of food components could be effective and the extent and the duration of the biological effect.
Based on these results lasofoxifene 0.5 mg/day was selected as the relevant dosage for the treatment of postmenopausal osteoporosis.
Glargine studies applying a more clinically relevant dosage scenario – on average a dose of 53 IU/day – showed that glycaemic control could be more improved than shown in the Heine trial; on average a further reduction of 0.65% in HbA1c.
The therapeutic dosage in this study is the clinically relevant dosage used in rodent studies to model type II diabetes.
However, neurotoxicity likely follows from exposure to relatively high amounts of dopamine [28], well in excess of physiologically relevant dosages.
These results clearly demonstrate significant differences of HES tissue storage between two HES specifications after repetetive administration of clinically relevant dosages.
Notably, MMF inhibited HIV-1 replication at clinically relevant dosages (1 10 μM) [ 9].
Toxic effects of MnCl2 at MRI contrast-relevant dosages in repetitive administration protocols were ruled out by histological and optometric examinations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com