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Like phase II trials, all participants have the relevant disease.
They use a very large participant group, all of whom have the relevant disease condition.
Consequently, reducing the disease module to a specific tissue acts as a natural filtering procedure, automatically eliminating the functionally and potentially mechanistically less relevant disease genes.
To demonstrate how tissue-specificity can be used to filter out less relevant disease gene associations we consider genes associated with macular degeneration and arthritis.
The examples of macular degeneration and arthritis demonstrate the possibility of using tissue-specificity of disease modules to filter out less relevant disease genes.
We discussed advantages and disadvantages of culture-based and culture-independent molecular diagnostics for detecting clinically and epidemiologically relevant disease.
The novel approach described herein allows for the preclinical study of nonadherence in etiologically relevant disease animal model systems.
Phase II trials are also used to determine the common short-term side effects and risks associated with the drug in patients with the relevant disease.
The main purpose of phase II is to gather preliminary evidence as to whether the potential drug helps participants with the relevant disease.
Similar(2)
The 'triplet repeat' neurodegenerative diseases are linked by a common mode of pathogenicity, wherein a polyglutamine expansion within the relevant disease-causing protein induces toxicity.
No relevant disease-specific measures or disease-specific preference-based tools were identified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com