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Overall, our results provide a comprehensive view of relevant copy number changes that might play a role in phenotypic differences among major human populations, and generate a list of interesting candidates for future studies.
Ovarian cancer is a heterogeneous disease displaying complex genomic alterations, and consequently, it has been difficult to determine the most relevant copy number alterations with the scale of studies to date.
DOC ratios can be used as an indication of the relevant copy number present in tumour sample compared to the matched normal sample.
Array comparative genome hybridization (array-CGH) methods provide high-throughput data on genetic copy numbers, but determining the clinically relevant copy number changes remains a challenge.
With the addition of SNP probes to our exon coverage array, we provide a comprehensive approach for the identification of clinically relevant copy number neutral changes in addition to medically actionable CNVs in a single assay.
Likewise, assays for therapy relevant copy number alterations can be easily designed (similar to ERBB2 locus investigated here) and enable faithful analysis of > 90% CTCs from GII categories 3 and 4.
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It took another year, until November of 2003, for the White House to allow four members of the commission to have a look at the relevant copies of the President's Daily Brief, the intelligence summary that goes to the President and a few other high officials each morning.
What we need to do is … find all the relevant or semantically equivalent relevant copies out there so that you can attach [them] to your local news… The president said something, you attach it.
Analysis of HPV-induced changes in the tumor methylome identified 453 regions of differential methylation with high confidence, given a 1% false-discovery rate for DMR identification and removal of DMRs falling into relevant copy-number variable regions.
This allowed us to detect clinically relevant copy-number aberrations, such as MYC/MYCN/GLI2 gene amplifications, from the FFPE as well as the frozen tumour samples (Fig. 1f, h).
Thus, Cre recombinase was active, and 8 10 days following virus injection, all functionally relevant copies of Munc18-1 proteins had disappeared from calyx terminals.
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