Sentence examples for relevant checkpoint from inspiring English sources

In the same way, this stretching could separate Aurora B from relevant checkpoint targets, such as BubR1/Mad3 [6], whose modification is important for spindle checkpoint arrest.

Thus we speculate that knockouts of these serpin genes result in de-repression of cell division following MMS treatment, thereby implicating AtSRP2 and AtSRP3 in the normal signal transduction required for the relevant checkpoint responses.

At the end of the song, she was standing alone at center stage, presumably with security guards hawkishly monitoring all the relevant checkpoints.

In response to DNA damage, relevant checkpoints can arrest the cell cycle at a certain stage.

If so, it may be that during 'normal' colony development on laboratory media, these brakes are all off – in other words, all relevant checkpoints have been passed, and the WhiJ-like proteins are not repressing their target genes.

It is currently unclear whether such subcomplexes (Rad9 Dpb11 9-1-1 or 9-1-1 Dpb11 Mec1 Ddc2) are relevant for checkpoint activation in wild-type cells, since their function can only be observed in mutant backgrounds and/or at high amounts of DNA damage and results only in partial checkpoint activation.

Applying this method to different tumor entities will rapidly increase the knowledge about therapeutically relevant immune-checkpoint molecules.

Apart from being expressed in tumor cells, it is also expressed in tumor-infiltrating lymphocytes (TILs), in which PD-L1 expression may be more relevant to immune checkpoint blockade response than its expression in tumor cells, i.e. a PD-1 signaling inhibitor may have no effect on a PD-L1 expressing tumor lacking an appropriate immune infiltrate.

Perhaps the most relevant approach to G2 checkpoint abrogation is the inhibition of Chk1 kinase.

Moreover, as reported for PNU-151807, the bromoacryloyl moiety seems to be relevant for cell cycle checkpoint control (Marchini et al, 1999).

In this review, we provide evidence of dysregulation of CTLA-4 and PD-1/PD-Ls in the context of several major types of hematological neoplasms and summarize relevant clinical practice points for checkpoint blockade.