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A DfE spokesperson says the second tweet accurately reflects underlying statistics, with a link to a document [pdf] where users could "find out more detail on how the data was collected and the relevant caveats".
Due to the short length and high variability of the sequences, the TFP superfamily is not an ideal candidate for sequence-based phylogenetic analyses, but the wealth of information that it could provide justifies the exercise, as long as measures are taken to minimize potential error and the relevant caveats are taken into account.
From a bioinformatics developer perspective, relevant caveats when designing a new software tool should include: (1) flexibility, i.e., how well does the software follow current standards and/or does it handle multiple vendor formats?
The relevant caveats around these findings included small studies over short term periods with varying interventions, and longer term larger studies need to be undertaken before making definitive statements of benefit.
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This is a particularly relevant caveat in the case of genomic regions that are inherently difficult to assemble correctly from Whole Genome Shotgun reads, and some of these regions identified in our study of primates, e.g. the major histocompatibility complex (MHC), fall into this category.
2) Some conclusions presented appear to be stronger than others, and the paper would benefit from inclusion of relevant experimental caveats.
Please address these issues experimentally or by inclusion of relevant discussion and caveats.
Several caveats are relevant to the interpretation of variations in HPV type distribution.
That caveat is especially relevant for 2012.
This caveat is particularly relevant for mosquitoes with relatively short flight ranges such as Cx.
Selecting a relevant cell line is a caveat of this approach, as the exact contribution of this genomic region to BMI is not fully understood, however a recent study suggests the contribution of variation at the FTO locus affects adipocyte lipid accumulation through increased IRX3 and IRX5 expression [ 40].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com