This concentration of VN/66-1 is biologically relevant, because it is well below the maximum plasma concentration (26.9 μ M), which was achieved in mice following a single subcutaneous administration of 10 mg kg−1 of VN/66-1 (Patet et al, 2007a).
The association with caffeine is relevant because of the well-known antagonism of adenosine A 2A) and A 2B) receptors, as well as the inhibition of cyclooxygenase activity at some sites, may explain intrinsic antinociceptive and adjuvant actions.
With regard to this possibility, the degree to which the hot spot-associated PPTs consist of short, direct tandem repeats (STRs, or microsatellites) is relevant, because microsatellites have well-described mutational dynamics [ 55], but it is unclear how a mutation bias could act on non-repetitive PPTs.
Arthur knows he's mostly able to stay relevant and draw attention because, well, he's a 60-year-old man claiming to be King Arthur.
This risk is particularly relevant, because HIV expenditures are currently well short of the annual global target of U.S. $22 billion to $24 billion.
This is relevant because their margins are still well below those of their competitors and fully-realized potential but steadily improving as Peter executes on the basic nuts-and-bolts of the turnaround.
The stratification for sex performed in this study is highly relevant, because the effect sizes as well as the prevalence of diseases and the prevalence of SHS exposure differ between the sexes.
SR: Well, it stays relevant because what happened on the home front is what is fueling their continued isolation on the island, and their inability to get home.
The retrofit of school buildings in Italy is relevant because of the poor energy performance of the stock, as well as for its high social value.
BOIES: Well, I think the case and the decision are relevant, because I think that what happens in the future is going to be determined by what the rules of the game are.
