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Diatom species are particularly relevant as model organisms because i) they are unicellular organisms easy to keep in culture, ii) they have a predominant role as primary producers, accounting for about 40% of the total carbon fixation in oceans and iii) any fluctuation at the population level of these organisms is expected to have major effects on the entire ecosystem [ 1].
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Further, many of these mutations in mice have proved to be medically relevant as models for human diseases involving the same genes [9].
Rhodopsin, thus, still remains relevant as a model system to study the molecular mechanisms of GPCR activation.
From a practical point of view this is relevant, as the model results suggest that intake fractions from indoor emissions are often larger than intake fractions from outdoor emissions.
The successful isolation of such fish in a screen based on funduscopy demonstrates that such screens are possible and are expected to lead to the isolation of interesting mutant lines, relevant as disease models of age related eye diseases.
However, a more direct strategy is desired for the increasing number of sequenced mammalian genomes of which some, such as the pig, are relevant as disease models and production animals.
The authors already did quite a good job on this point, but it can be made more extensive, which in this case is relevant as the models concern mostly global mutants.
This allows interesting applications, such as modeling identity by descent probabilities for estimation of gEBV and QTL detection, or models where parent of origin is relevant, such as models with imprinting or crossbreeding effects [ 27].
This research will be particularly relevant as the continuous model component constitutes a non-linear mixed model.
This latter class of models seems particularly relevant as agent-based models typically consist of some latent and some observable variables since not all the characteristics of agents would mostly be observable.
In order to improve the rhesus model of gluten sensitivity and to make it more relevant as a CD model, selection of gluten-sensitive macaques will need to be carried out in future also in the context of MamuII pre-screening.
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