Sentence examples for relevant altered from inspiring English sources

†Includes myopathy with statin treatment, or clinically relevant altered plasma concentration (for example, of digoxin, lithium, ciclosporin, or theophylline), which might require dose alteration or closer monitoring.

To address whether TTLshort/early-relapse leukemia is characterized by functionally relevant altered apoptosis signaling, we analyzed apoptosome function in patient derived ALL xenografts and evaluated its impact on NOD/SCID/huALL engraftment, treatment response and overall patient survival.

Less stringent parameters (5% FDR for CD34+ or 15% for stromal cells) were used for generating a list of altered genes that was uploaded to Ingenuity Pathways Analysis (IPA) software (Ingenuity® Systems, http://www.ingenuity.com) for identification of relevant altered gene networks.

The number of cisplatin-modulated genes showing a statistically relevant altered expression (p value<10−5) was higher among diploid than among tetraploid cells (Fig. 7A,B), correlating with the higher susceptibility of diploid cells to cisplatin-induced killing (Fig. 6D).

A figure with the representation for all the 22 human chromosomes for the GBM samples is included as Additional File 3. As shown in Figure 3, the method presented in this work allows the identification of relevant altered genomic regions suffering significant changes in most of the GBM samples.

In this review, we will provide a general overview of sex differences in the early developing brain that may be relevant for altered seizure susceptibility in early life, focusing on limbic areas of the brain.

This observation prompted us to determine the host reaction to different leptospiral isolates in a relevant minimally altered physiological system.

To elucidate functional HIF-1α regulation, we exposed thyroid cancer cell lines to graded hypoxia or stimulation by a biochemical hypoxia mimetic cobalt chloride (CoCl2) and tested the impact of inhibitors on the relevant genetically altered pathways in these cells.

To investigate non-cell-type-specific, pathologically relevant pathways altered by LMNB1 overexpression, we performed whole-genome RNA profiling on human skin fibroblasts and whole blood of subjects with LMNB1 duplications versus controls.

A better understanding of these mineralisation dynamics is clinically and biomechanically relevant because altered muscular forces have been shown to increase fragility [24]; moreover, skeletal deformability has been shown to increase in bone disorders mediated by weaker muscle forces, such as muscular dystrophy [25] and hypophosphatemic rickets [26].

A detailed report including the list of genes related to specific GOA terms is available at Additional File 1. Biological filtering through the use of databases led to the functional classification of the nodes forming the iHSLN into: (1) cancer-related genes, (2) genes related to the DNA repair mechanism and cell cycle (two relevant functions altered in most cancers) and (3) drug-target genes.