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The finding underscores the idea that, in a situation in which the non-occurrence of reward may or may not have behavioral relevance, as in our task, the electrocortical response to the behaviorally relevant absence of an outcome overrides the effect of the simple processing of a disadvantageous outcome.
While activation of the posterior medial OFC in the processing of outcomes devoid of any tangible reward value [41] and early signaling of behaviorally relevant absence of outcomes at 200 300 ms in such a task [42] has been observed before, the processing of behavioral relevance and hedonic loss of the absence of anticipated rewards have never been directly compared.
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This study employed simulation strategies to explore this relationship in the simplest relevant system (absence of protein binding, saturable uptake, or metabolism at the BBB).
Previous work has been hampered by a narrow focus on only one type of risk (such as coronary disease), a lack of completeness in identifying all relevant studies, absence of quantitative synthesis through conventional meta-analytic techniques, and failure to use a validated tool to assess the quality of studies.
The abovementioned 10 years will be extended by any maternity leave(s) or other relevant leaves of absence.
I wrote only the former, the one about the subject, and I kept my adventures out of it; even so, they're relevant in their absence, because, for a biography to be worthwhile, it must also be personal.
Therefore, this thought experiment is relevant in the absence of an applied technology.
But whether the patient could in fact afford the study (a question wholly relevant in the absence of EMTALA-like legislation) was not recorded.
Despite this limitation, we suggest that to date, sAA is the best surrogate salivary marker for SNS activity, which is relevant in the absence of available blood tests and if restricted to salivary analyses.
But the Warrior hadn't yet become sufficiently relevant that his absence from the scheduled card had been noticed.
Most importantly however, Krm2-deficient mice also display a high trabecular bone mass phenotype at 24 weeks of age, which is especially relevant given the absence of obvious abnormalities outside the skeleton.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com