Sentence examples for relevant aberration from inspiring English sources

Using an informed, sophisticated approach to array design, more of these optimized probes have been placed in regions of the genome that are most likely to detect a biologically relevant aberration.

Relevant aberrations in PTEN and PI3K levels can be detected by IHC.

Detection rates of these clinically relevant aberrations were slightly comparable between the three studied genital conditions (25% for ambiguous genitalia, 17.2% for hypospadias and 18.5% for cryptorchidism) (Table 1).

approach, however, is that it fails to identify other potentially relevant aberrations that may impact on clinical decisions [ 3].

However, the extensive and complex nature of chromosomes makes it difficult to identify the biologically relevant aberrations and functional significance.

We identified relevant aberrations, including deleterious mutations of KRAS and SMAD4 as well as a homozygous focal deletion of the PTEN tumor suppressor gene.

Amongst all the relevant aberrations, the most consistent gain in BRCA1-mutated TNBC was a highly significant (P = 0.0002) and recurrent gain of 2.4 Mb located between the position 78644018 and 81029941 on the chromosome 17 (17q25.3 (Human Genome built 37)).

To find potential relevant aberrations for clinical decision making, this study correlates CNAs of a panel of 36 common oncogenes and tumor suppressor genes in two major subsites of HNSCC, knowingly the oral cavity and the oropharynx, with both clinicopathological features and survival.

Functional magnetic resonance imaging (fMRI) has helped to elucidate the neurobiological bases of psychiatric and neurodevelopmental disorders by localizing etiologically-relevant aberrations in brain function.

In addition, our data shows examples of clinically-relevant aberrations that demonstrate the potential utility of the OncoScan® assay as a robust clinical tool for guiding tumour therapy.

This questions the efficiency of current methods that target only a handful of common aberrations in specific tumour types and points to the need for wider profiling of clinically-relevant aberrations regardless of tumour type.