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To gain insight into whether the SOC current inhibitory effect of P100 may have physiological relevance, we used the mutant P100 expression construct bearing the disease-causing R4227X mutation and tested for the effect of the mutation on SOC current inhibition.
Class-I and class-II whistles were chosen for their social relevance: we used each type of class I universal whistles that are usually used in male-male interactions, and unfamiliar, familiar and bird's own exemplars of class II individual-specific whistles [31].
To cover specific issues of relevance, we used data from the above-mentioned four data sets, selecting the most appropriate for any given purpose.
To improve clinical relevance, we used the dichotomous variable 'presence of anxiety or depression' (yes/no) with pre-established cutoff points for anxiety and depression (HADS-A score ≥11 or CES-D score ≥16) for the final analysis [ 20, 22].
To indicate clinical relevance we used the minimal important difference (MID), defined as the smallest change in a patient-reported outcome that is perceived by patients as beneficial or that would result in a change of treatment.
Next, to examine whether using TD52 to enhance PP2A activity has potential clinical relevance, we used a PLC5 xenograft mouse model to assess the effects of TD52 in vivo.
Similar(53)
As relevance function rel we used the sum of the amount spent.
Moreover, also the amount spent is not available, thus as relevance function rel we used the sum of the number of items purchased in each shopping session.
To precisely determine the functional relevance of PAFR, we used PAFR-deficient mice (pafr−/− mice) [36].
To assess relevance to tumorigenesis, we used 3D models of mammary cells.
In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448).
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