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In general, good SBA titers were found against the selected MenB reference strains and no influence of clinical relevance was observed regarding the immune response against routine infant vaccines.
Importantly, evidence of the potential clinical relevance was observed in a cohort of ER-positive breast cancer patients who received tamoxifen therapy, where high levels of Sox2 correlated with endocrine treatment failure and poor relapse-free survival.
When stratified by dominant ethnicity, no significant relevance was observed in both Caucasians (random-effects model: pooled HR = 1.05; 95% CI: 0.51 2.17; P = 0.887) and Asians (random-effects model: pooled HR = 1.49; 95% CI: 0.48 4.66; P = 0.493)).
For the studies evaluating OS for miR-141, a random-effects model was used to calculate the pooled HR with 95% CI due to the significant heterogeneity (I = 74.2%, P = 0.000), and no statistically significant relevance was observed (pooled HR = 1.18; 95% CI: 0.74 1.88; P = 0.482)).
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In this surveillance, low Ct-values, potentially suggesting etiological relevance, were observed for more than one pathogen in several instances.
The first signs of de novo antibiotic resistance of clinical relevance were observed in Mycobacterium tuberculosis soon after the introduction of streptomycin in infected patients (Crofton and Mitchison 1948; Youmans and Williston 1948).
Apart from the caucasian founder mutation E265X, a missense change of unknown relevance, R400P, was observed in our study samples.
Obvious physiological relevance of these results was observed in the susceptible genes identified for bipolar disorder, including INPP5B (MIM, 147264), POU3F1 (MIM, 602479), MTF1 (MIM, 600172), CCDC91 (coiled-coil domain containing 91), KCNQ5 (MIM 607357) and Olfactory receptors (OR4K5, OR4K2, OR4M1, OR4K1, OR4N2, OR4K14, OR4K13; 14q11.2).
Conversely, no evidence of prognostic relevance of marker expression was observed in tumor cells.
No prognostic relevance of the different markers was observed in the overall series (Table 2).
However, no statistical significance was observed for the relevance and confidence factors.
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