Although we found evidence of added value of OPG in risk reclassification for the endpoints cardiovascular death and HF, the clinical relevance of OPG will depend on whether or not therapeutic relevance is established.
It would substantially strengthen the paper if biological relevance were established with either a more specific perturbation and/or a more specific assay for ER exit (as opposed to cell death).
Face validity for the survey pre/postunit constructs (awareness, self-efficacy, engagement, as well as relevance for students) was established through an iterative item-construction process by the research team, and the content validity of the four constructs was empirically tested using exploratory factor analysis (EFA) of the preunit survey items (Stevens, 2002; Tabachnick and Fidell, 2007).
The in vivo functional relevance of autophagy in PCs was established by two key observations.
The clinical relevance of the PPARγ pathway was established ever since its identification as a high-affinity target of the anti-diabetic drugs thiazolidinediones (TZDs) (3).
Lastly, the physiological relevance of the insertion model was established by independent genetic rescue experiments in the Drosophila neuromuscular junction, wherein mutations in CPX that are predicted to prevent the formation of the SNAREpin array were found to disrupt the ability of CPX to clamp spontaneous release (Cho et al., 2014).
The biological relevance of the derived motifs was established by an algorithmic procedure, where each motif is used as input for genome-wide screening (Motif Searching) and the genes found to contain matching sequences within their promoter regions are tested through the Hypergeometric Test for Gene Ontology Term overrepresentation.
---Relevance Thestablishedandestablishedevelopedeloped in response to the dire situation in Nkandla municipality where 61% of children lived in poverty.
For the time being, in vivo responses to a pro-inflammatory challenge are a group C marker for inflammation control, but they may evolve to a group A marker if relevance can be established in prospective cohorts in the general population.
