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Moreover, the identification of two recurrent BRCA2 mutations predisposing to MBC may be of practical relevance to optimize the molecular analyses aimed at detecting mutation carriers in North East of Italy.
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The method also allows rationalizing the relevance of the signals to optimize the decision-making process.
Couched within Sperber and Wilson's (1986) relevance theory, the paper makes the claim that headlines are designed to optimize the relevance of their stories for their readers: Headlines provide the readers with the optimal ratio between contextual effect and processing effort, and direct readers to construct the optimal context for interpretation.
Therefore, locomotor costs are driven more by ecological relevance than by the need to optimize locomotor economy.
We asked the patient to identify activities involving the hand eligible for hand surgery in order to optimize the relevance of the instrument.
An observational study may be helpful in the debate on actual clinical relevance and provide lead points to optimize staging in clinical practice.
In order to optimize the relevance of the instrument across a wide range of age groups, the study authors attempted to achieve an equal distribution of children within three groups: premature infants to three months, four to 11 months and 12 months to 12 years.
Our model can easily be adapted using local and updated data to optimize its local relevance.
8 In order to optimize the physiological relevance of our results, we used outdated peripheral blood from healthy volunteers, as supplied by the French blood bank.
The survey was tested by eleven Dutch experts in the field of lithium treatment (Additional file 2: Appendix S2) to optimize content on appropriateness, relevance, and time to complete the survey, and it was adjusted accordingly.
In particular, we modified the objective function to include the stream relevance weights and derived the necessary conditions to optimize all of the model parameters simultaneously.
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