Beyond changes in paracetamol disposition, we hypothesize that this pattern of raised phenotypic glucuronidation driven by pregnancy or oral contraceptives is of relevance to explain and predict within and between individual variability in disposition of drugs that mainly undergo UDP-glucuronosyltransferase (UGT 1A6, 1A1, 1A9 or 2B15 driven glucuronidation.
Model validation yielded satisfactory results indicating relevance of the model to explain ACE inhibition while ultrasound pretreatment showed strongest effect on ACE inhibition of MPC hydrolysates.
Specifically, we compared strategies designed to explain relevance and provide choice.
Table 1 presents the parameters of a high relevance logistic regression model to explain the phenomenon of taking the decision to emigrate (P = 0.0000).
"Scientists have a responsibility to explain the relevance of their work to the people they hope to study," he writes, "in order for their participation to become what it really is -- a collaborative research effort".
The ABC is forced to explain its relevance in the face of ongoing attacks, when its charter prioritises the very things its commercial critics would see diminished: multiculturalism, education, diversity – and independence.
Too few scientists are willing to engage in public debates, to explain the relevance of their fields clearly and without jargon, and, in the process, to risk some jeering from a few colleagues.
As he turns 60, he is struggling to explain the relevance of his lifetime experience, both to party insiders who have long had mixed feelings about him and to a new generation of antiwar activists for whom Vietnam is distant history.
He held forth on how Bedouin poetry shaped a moderate Islam in Libya, and he was just starting to explain the relevance to Libyan politics of the mathematical theory of complexity — it had to do with something called "flocking phenomena" — when his cellphone rang.
A lot of was spent on advertising to explain the relevance of mouthwash to these consumers.
