Clarification of the strength of these protective effects, the clinical relevance of these effects and determination of which statins are most effective is needed.
This approach leaves huge questions about the relevance of these effects to human health, and in the case of phthalates, their relevance to the health of children.
However, the relevance of these effects to discs in vivo remains unclear.
The clinical relevance of these effects is unknown and requires investigation.
Considering the clinical relevance of these effects, studies directly comparing the effects on tumor angiogenesis of fractionated vs single high-dose treatments are needed.
Further investigations are warranted to evaluate the clinical relevance of these effects.
An understanding of the underlying mechanisms of interaction may help assessment of the clinical relevance of these effects.
Historically, toxicologic studies of phthalates have focused on liver effects in rodents and the toxicologic relevance of these effects to humans (European Commission 2003a, 2003b).
A modest short-term effect over placebo on lipid-lowering seems to be established but the clinical relevance of these effects is uncertain.
Due in part to species-specific metabolic differences, the relevance of these effects to humans is questionable [ International Agency for Research on Cancer IARCC) 2000; Klaunig et al. 2003].
