Progress in treating the human form of cancer cachexia can only move forwards through carefully designed large randomised controlled clinical trials of specific therapies with validated biomarkers of relevance to underlying mechanisms.
Despite the prominence of these models, we have surprisingly little evidence to date on the relevance of the underlying microeconomic mechanisms (Goldberg et al. 2010).
MAGMa+ shared the best ranking for 44 of 208 challenges (see Table 2) and performed considerably better than other contestants for nine of those challenges (21, 32, 36, 40, 52, 61, 121, 157 and 189), indicating the relevance of the underlying algorithm.
Unbiased analysis of the biological relevance of the underlying rules by Pathway Studio resulted in the identification of pathways with known pathogenetic or therapeutic relevance in RA.
The purpose of untargeted metabolic profiling in our work was to sample metabolic diversity without bias for the biological activity or practical relevance of the underlying compounds.
Unbiased analysis of the biological relevance of the underlying rules by Pathway Studio (Elsevier, Munich, Germany) and gene enrichment analysis succeeded in identifying pathways with pathogenetic or therapeutic relevance in RA.
The clinical relevance of possible underlying pathophysiological mechanisms remains unclear, although elevated glycosylated hemoglobin (HbA1c) levels appear to increase the risk of dementia [ 12], and treatments improving glycemic control may therefore reduce the risk of dementia.
The consistency of the different approaches for outlier detection (supplementary fig. S3, Supplementary Material online) and the functional relevance of the underlying genes strongly suggest that the majority of the identified loci and their associated genomic regions is subject to divergent selection (see however Bierne et al. 2013).
All these studies confirmed the clinical relevance of GM involvement, underlying the inhomogeneity of cortical alterations.
Many participants found it difficult to evaluate the relevance of the reasons underlying many of the MOHLTC directives because the directives did not explicitly describe the reasoning involved.
