A series of experiments now needs to be done for each antigen to verify the immunological relevance of the patterns observed, the haplotypes from each subgroup that will elicit broadly protective immune responses, and to quantify the contribution of each polymorphism to antigenic diversity.
As one measure of the relevance of the patterns of pathway activation, we examined the clinical outcome of patients identified by these patterns of pathway activation.
To assess the biological relevance of the patterns found, we examined whether known lung cancer genes were classified as "exclusively amplified" or "exclusively deleted" recurrent CNAs.
The relative activation of the epigenetic pathways in the thyroid, breast, non-small cell lung, liver, colon, and esophagus cancers mirrored what we saw in the cell lines, confirming the relevance of the patterns seen in the cell lines.
The health relevance of the patterns was supported by expected correlations with a broad set of criteria such as depression, well-being, sickness, absence, blood pressure, heart rate, type-A behaviour or burnout.
The relevance of this pattern is not so clear because the confidence limits for univariate characters are considerably large and much of the size disparity fluctuation within lineages falls inside the confidence intervals.
Taking all our observations together, we can propose a mechanistic model how PTM patterns correlate with genetic activity and the relevance of this pattern for genes during a differentiation process.
The relevance of these patterns is that the national data for the period 1986–1999 do not comprise a consistently defined group of bladder cancers.
Longitudinal follow-up (with clinical, PIB and CSF measures) of such subjects will be important for understanding the biological relevance of this pattern.
In a next step we used probability maps based on those fields and prevailing rainfall intensities to assess the hydrological relevance of the detected pattern.
