Long-term evidence has supported the relevance of TNM staging or other readily ascertainable clinical characteristics.
With the shift that mammographic screening causes in stage distribution, this issue has become increasingly important, with a high proportion of tumors being T1N0M0 at diagnosis, thereby limiting the relevance of TNM staging in routine practice.
The functional relevance of these stages and their alternations is unknown, although depriving subjects of either stage can induce detrimental effects independent of sleep loss itself, and a rebound amount of time spent in the deprived state in subsequent sleep episodes [1] [5].
Because of the uncertain clinical relevance of GOLD stage I COPD, data for this group are presented separately from those for GOLD stages II+ (moderate to very severe airway obstruction), and most analyses focus on comparing the latter group to the unobstructed-airways group.
Our aim is to identify the potential relevance of possible stage-matched interventions regarding Dutch alcohol consumption guidelines.
As this figure would probably decrease at less experienced centers, our information makes rather feeble the epidemiological relevance of this stage in clinical practice.
The early detection of these metastatic or recurrent lesions is of high clinical relevance for staging, prognosis, and therapy management [1, 2].
Considering potentially curable mCRC, the relevance and outcomes of staging before treatment is most well-known for liver metastases.
In conclusion, we found no prognostic role for Goseki or other traditional histological classification systems or for Siewert topographical classification; however, we did confirm the relevance of the TNM staging system as the most important predictor of survival in patients with adenocarcinoma of the cardia.
However, given this difference in origin, the feature importances assigned to marks from before and after the target stage may not be directly comparable representations of the relevance of these developmental stages to the target.
