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Therefore, we also evaluated the clinical relevance of this simulation model.
In summary, our aMD simulations show that the receptor empty form and bound to two agonists converts to the inactive-like state with recovery of known microscopic interactions of the inactive state in the nanosecond time scale within three conducted replicates of simulations, indicating the relevance of aMD simulations in the active-to-inactive state transition.
In the case we were to judge the relevance of these simulation results within an evolutionary context, the implications of weak mutational effects for the dynamics of adaption processes would not be clear at all.
The key issue is that to what extent that the simplifications or assumptions may affect the results, influencing the relevance of the simulation to the realistic situation.
These three have been selected because of their relevance to simulation-based clinical training.
The practical relevance of such simulations will be enhanced by a better understanding of the correlations between pathology and specific mechanical loads.
The material presented is of particular relevance to the simulation of industrial metal forming operations characterised by the presence of extreme deformations and strains, often resulting in localised material deterioration with possible fracture nucleation and growth.
The relevance of this last simulation exercise is revealed in Table 2 and Fig. 2.
The relevance of the other simulation parameters is almost negligible (it is not the case, however for the prediction of PB): using more inputs would lead to a more complicated regression and to a possible over-fitting of the data.
The clinical relevance of these simulated corrections was evaluated by comparing the values obtained from the simulations with those measured on the postoperative CT taken for each patient.
Strengths of the simulation model presented in this study include the clinical relevance of the model, which captures the situation faced by the post-acute care population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com