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In the last decade European accidentology data, divided per mode of transport, have shown the increasing relevance of safety for Vulnerable Road User (VRU).
However, recent advances in the biosciences provide exciting opportunities to accelerate this process and to ensure that the alternative paradigms for hazard identification and risk assessment deliver lasting 3Rs benefits, whilst improving the quality and relevance of safety assessment.
Such approaches promise to increase the human relevance of safety assessment, and shift the focus from hazard-driven to risk-driven strategies similar to those used in the pharmaceutical sectors.
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The animal model and treatment schedule selection and the parameters investigated are critical for the relevance of this safety assessment.
Table 2 reports on the reported perceived relevance of patient safety items.
To further establish the relevance of the safety of multi-ingredient formulae to psychiatry, it is useful to address the available evidence on efficacy.
Estimates of mass flux values (kg/m2 s) are obtained and assessed with regard to relevance for safety assessments of molten salt breeder blanket designs.
The relevance of patient education safety programs has been put forward by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) (http://www.jointcommission.org/speakup.aspx).org/speakup.aspx
A tension between scientific and societal relevance of the notion of safety was noted, raising doubts about the scientific validity of safety science (Safety Science, 2014).
The present paper outlines key design features of relevance for the safety of international thermonuclear experimental reactor (ITER) and fusion devices of reactor scale.
Consequently, this biomarker may be of relevance in safety assessment, in particular for new drug candidates exhibiting hERG-blocking properties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com