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The case indicated the relevance of process control and appropriate characterization methods application, to keep the dissolution and bioavailability of low solubility APIs categorized (BCS 2 or 4), particularly in formulations that use dissolution-enhancing technologies.
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Perhaps, the greatest challenge is to understand the relevance of processes occurring at one scale for patterns at another (Tomlinson and Bodmer 1999).
Beside the interest in characterizing this novel producer of microbisporicin, this paper drives the attention to the relevance of the process termed dereplication, that is, the process of distinguishing those microbial extracts that contain known bioactive metabolites from those that contain novel compounds of interest, saving resources and speeding up the discovery process of novel drugs.
A typical process route is defined to expose the relevance of key process variables, including source remoteness and water reclamation both from tailing storage facilities and thickeners.
The lower the P value is obtained, the higher the relevance of this process network to the candidate target genes and the rating of this process network are indicated.
The relevance of this process lays in its triggering effect of toughening mechanisms in polymer based composites.
The biological relevance of this process has been discussed controversially, especially because of the lack of rate constants.
Which could be the biological relevance of this process?
The physiological relevance of this process has yet to be determined, but it could be related to limit the iron uptake by bacteria or to avoid an exacerbated accumulation of reactive iron (II) levels.
The next-generation sequencing and other high throughput methods have underlined the relevance of epigenetic process in cellular homeostasis.
To improve our understanding of the relevance of this process to rheumatoid arthritis (RA), we have studied the mechanisms of presentation of exogenous CXCL12 by cultured RA ECs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com