Collectively, these lines of evidence partly explain the relevance of post-translational modification and switch of E2F1's activity towards regulating cell survival or apoptosis.
In the current work we studied the relevance of post-translational histone modifications for gene activation, analysed their dynamics on nanochromosomes specifically activated during sexual reproduction and their fate during a nuclear differentiation process.
Clearly, the available literature reveals just the tip of the iceberg, and exact molecular mechanisms in, and the biological relevance of post-translational regulation of polycomb function await further elucidation.
The non-encouraging trend of maternal deaths compared to infant deaths also highlights the relevance of post-partum care, as substantial share of maternal deaths might occur around the post-partum period [ 22, 23].
We found that the correlation of the protein-level changes with those of the corresponding mRNAs was significant, though weak, in each of the four conditions; although it is considerably weaker in carbon limitation (R: Carbon = 0.44, Nitrogen = 0.60, Phosphorus = 0.55, Sulphur = 0.59; P < 1 × 10-16 in all cases), showing the relevance of post-transcriptional control of cell growth.
Finally, the prognostic impact of the lymphocytic profile change has not been formally evaluated, and the only publication addressing the relevance of post-NCT lymphocytic infiltration in the residual tumor is confined to triple negative breast cancer and does not include data regarding the different lymphocyte sets [ 26].
However, the prognostic relevance of post-NCT immune cluster groups was apparently independent of the pre-NCT group (A, B or C) as suggested by the stratified DFS analysis (P = 0.07; log-rank) in which the deleterious prognostic impact of cluster Y was observed among all pre-treatment clusters groups.
The numerical modeling of grain drying is a topic of great relevance to post-harvest engineering.
Given the importance of post-translational modification in regulating E2F1's activity and biological effects, it is important that future studies examine the clinical relevance of various post-translational modifications of E2F1.
But raising an alternative or an improvement to ELSI research, presupposes that there exists a form of research that is rightfully called ELSI – just as the relevance of a post-modern challenge presupposed that there was something rightfully called modern (Latour [1993], 10).
Future research will clarify the functional relevance of this post-conceptual operation for language understanding.
