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We discuss the use of DES in reliability and availability studies, not only as an alternative to the use of analytical and probabilistic methods, but also as a complementary way to: (i) achieve a better understanding of the system internal behavior and (ii) find out the relevance of each component under reliability/availability considerations.
As a more cogent test of the functional relevance of each component, we next asked whether the ability of CBX7 to downregulate p16INK4a was dependent on either BMI1 or MEL18.
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To evaluate the relevance of each NPI component to the survival of TNBC patients we used the follow-up data available for the TNBC cohort and survival curves were estimated by the Kaplan-Meier method.
In considering the need for a new scoping study, the value and relevance of each of these components needs to be considered and eliminated where appropriate, according to the declared aims of the scoping exercise.
Understanding of the applicability and practical relevance of each of these four components is important when interpreting cardiac output values.
Although most clinicians should/will be able to recite the four determinants of cardiac output – heart rate, contractility, preload, and afterload – understanding of the applicability and practical relevance of each of these four components is all too often less well ingrained.
Our findings support the clinical relevance of MetS component detection, which may be a simple, quick tool to stratify diabetic patients according to the expected macrovascular complication severity (as a polydistrectual disease).
Those advantages include: (1) the maintenance of the complexity and relevance of the bone component of this 'microenvironment'; (2) the distinct separation of the biological components to allow accurate analyses of each component; and (3) the ease of in vitro manipulation of all biological components.
Whereas, the null correlation between the cycle and trend lead to a higher relevance of the cyclical component.
Further experiments are required to establish which proportion of the induced miR164 accumulation is due to the transcriptional effect, which is the precise mechanism involved and to uncover which is the biological relevance of this transcriptional component.
The practical relevance of the variance component for imperfect blending of samples was further investigated by comparing the number of transcripts identified as differentially expressed in different treatment levels by means of the full model (m2, Eq. 1) and the null model (m1) y= X β + Z1 u1+ e without a random effect of imperfect blending.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com