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Moreover, the relevance of conclusions drawn from animal data for human skin has always been questionable.
This result challenges the general relevance of conclusions from laboratory systems that consist of a single combination of mosquito and DENV genotypes.
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This cannot stand alone without the fourth part, in which the clinical relevance of the conclusions are set forth.
The relevance of these conclusions to more generic ecological theory is discussed in the context of evolutionary forces acting on hunter gatherer mobility in prehistory.
Unfortunately, methodological issues might limit the relevance of the conclusions: First, the increase in Pcv-aCO2 not only was quantitatively minor and insignificant from a clinical point of view, but mainly stayed within the error of the method of PCO2 measurement.
We provide here some promising data that supports in vivo relevance of our conclusions.
The cross-validation of the results in the different cohorts also guarantees the reliability and relevance of our conclusions.
The application of our analysis on data from other countries could show the cross-country relevance of our conclusions.
Given the relevance of the conclusions deriving from this work, it is essential that possible biological artefacts be ruled out.
Suspensions of GUVs are relatively well controlled but the biological relevance of the conclusions is limited due to the simplicity of the system.
The findings of these analyses are explained in the manuscript and are aimed at improving the clinical relevance of the conclusions drawn.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com