The precise mechanism of action and the relevance of combinations of stimulus parameters are still unclear.
This framework is based on a scenario approach that encompasses normative, exploratory and optimized scenarios to assess the relevance of combinations of new agricultural policies, changes to the external context (market and regulations) and innovations in cropping systems.
Besides well-documented threats such as habitat degradation, the decline of wild prey populations and human persecution, the relevance of the combination of two additional factors - changes in livestock managing including the regular use of veterinary drugs, and disease - has recently become apparent [1], [4] [6].
For this reason, in vivo testing should be considered for further elucidation of the clinical relevance of the combination of ET-743 and radiotherapy.
However, the results of the addition of these two treatments are puzzling, leaving unresolved the questionable clinical relevance of this combination and the possible increase in bleeding risk.
Such an effect would not have been identified if a separated analysis of each MMP genotype had been performed, underlining the relevance of the combination test.
Notably, synergy with BIRD-2 and ABT-263 was still present at high drug effect levels, emphasizing the potential therapeutic relevance of this combination.
As the number of patients carrying both alleles is limited, the biological relevance of the combination of GBA and COQ2 variants in the pathogenesis of MSA remains to be determined.
The study points out the importance of interactions among the BPI, LBP, TLR, HSP 70 and IL-6 polymorphisms and also highlights the relevance of the combination of gene polymorphisms to sepsis outcome.
Finally, the combination of the three kernels presents an advantage over each single kernel in almost all measures in both Human and Drosophila, showing a certain relevance of their combination.
