Sentence examples for relevance of cells from inspiring English sources

However, the identity and the physiological relevance of cells derived in vitro from pluripotent sources are unclear because cells could acquire transcriptional and epigenetic programs in vitro that diverge from cell states in vivo16.

This may indicate that surgical manipulation of the primary tumours in these individuals has resulted in dissemination of tumour cells into the circulation but the clinical relevance of cells disseminated by surgery is a subject of debate.

There is an ongoing debate about the presence and relevance of cells in the mid-myocardium with prolonged AP duration [see the recent M-cells debate in the Heart Rhythm journal (Janse et al., 2011; Nattel et al., 2011; Wilson et al., 2011)], which highlights that heterogeneity throughout the heart is poorly understood at present.

The relevance of cell-cycle inhibitors in preventing replicative stress may have important clinical implications in different tissues.

These results reveal the relevance of cell cycle control pathways in the cytotoxicity induced by the TK/GCV system identifying candidate genes as conditioners of TK/GCV sensitivity.

The relevance of cell cycle control was further demonstrated by experiments showing the association of Chk1 activation with greater TK/GCV cytotoxicity.

There is an increasing demand for such studies to address how replication is regulated during development, its relationship to chromatin architecture and other chromosome functions, and the relevance of cell culture models to regulation in the native organismal niche.

To understand the in vivo relevance of cell-autonomous immune functions, we engineer and study genetic mouse models that include, for example, mice bearing Cas9/sgRNA-induced loss-of function aloss-of functionhost defense genes.

Furthermore, an artificial 3D environment can be used to improve the physiological relevance of cell or tissue and to reduce the gap between the in vitro system and the in vivo state, which emphasizes the importance of 3D environment [2, 3].

In a variety of studies with adult and embryonic stem cells the relevance of cell-cell interactions for maintaining "stemness" has been demonstrated [16], [28], [29].

It is impossible to overstate the relevance of cell death research to human pathology.