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To investigate the functional relevance of Bid for the synergistic induction of apoptosis by ABT-737 and TRAIL, we silenced Bid by RNA interference (RNAi).
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In contrast, transfection with control siRNA did not alter Fas-induced apoptosis, indicating the relevance of the Bid protein in apoptosis induced by anti-Fas, and consequently the connection between intrinsic and extrinsic pathways.
Two different active fragments of Bid have been described: truncated Bid, or t-Bid, [ 27] and j-Bid [ 3].
Alternatively, caspase-8 cleaves BH3-only protein, Bid, to generate the truncated form of Bid, t-Bid [ 31].
But in a bid to gain legitimacy, most organisations have recognized the relevance of their environment to their businesses and the need to safeguard it.
The relevance of relevance.
The relevance of character.
The relevance of "Checkers" is undeniable.
They questioned the relevance of their work.
What is the relevance of all this?
Black Americans have long recognized the relevance of the Haitian Revolution.
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