The structure of the network might be modified, as well as the relevance of some agents with respect to the connectivity or the diffusion of knowledge; the polarization of agents and the average number of topics that agents learn from interactions with others could also be reduced.
Infections account for about 66% and 72% of deaths among wild chimpanzee and extant human traditional societies, respectively (Finch 2010); these figures underscore the relevance of infectious agents as powerful selective forces during the evolutionary history of Primates and, most likely, of other mammals.
This paper summarises current knowledge of the incretin effect as well as the incretin-based therapies that are available for the management of type 2 diabetes, and provides suggestions for the potential relevance of these agents in the management of dysglycaemia in the critically ill, particularly to normalise elevated blood glucose levels.
To demonstrate the functionality and therapeutic relevance of the IDEPT agent, in vitro cytotoxicity assays were performed.
The use of patient samples, however, is important in predicting the clinical relevance of novel anticancer agents, and here we also show PBOX-15-induced apoptosis in ex vivo myeloma cells isolated from patient bone marrow aspirates.
The public health relevance of some of these agents (e.g., new lyssaviruses and morbilliviruses) is not yet fully assessed.
The current debate about the side effects of induction agents, e.g. possible adrenal suppression through etomidate, emphasizes the relevance of choosing the correct induction agent in septic patients.
For instance, Hitchcock emphasizes that it is important to consider what the bookie knows in assessing the relevance of Dutch Books on an agent's rationality (Hitchcock 2004).
Another finding has shown that EGCG inhibited growth of the mouse viral mammary epithelial carcinogenesis model; induced apoptosis and finding suggest the clinical relevance of EGCG as a chemopreventive agent [ 9].
With the introduction of targeted agents, the relevance of prognostic and predictive markers in patient selection has become increasingly relevant.
Moreover, they emphasize the relevance of genetically assessing the effectiveness of agents targeting neurons during ALS evolution.
