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Exact(11)
Conclusive categories are assigned when a conclusion about the reliability and relevance of a study can be drawn (for reliability: R1, R2, R3; for relevance: C1, C2, C3).
Available European guidance documents, e.g., the REACH guidance document, the European Commission's Technical Guidance Document (TGD) [7], and WFD [8], do not provide detailed information on how to evaluate reliability and relevance of a study.
Since the relevance of a study can vary depending on the regulatory context, risk assessors were informed prior to the evaluation to assume that the studies should be evaluated for their potential use in derivation of EQC within the Water Framework Directive, where all endpoints with known population relevant effects are accepted [4].
Generalizability is characterized by the relevance of a study's results when applied to a larger population.
Without due consideration, there can be result conflicting data interpretations and uncertainty about the relevance of a study's results to human risk.
Any disagreement between the reviewers regarding the relevance of a study was resolved by consensus.
Similar(49)
The relevance of such a study is growing, because of recent trends that may decrease the levels of safe practice exactly at ages in which the child's brain is optimally 'wired' to learn new skills [ 15].
Overall, the ring test showed that both evaluation methods provide similar results regarding the relevance evaluation of a study, even though a differentiation between "relevant without restrictions" and "relevant with restrictions" is not foreseen in the Klimisch system.
Despite being limited by the above cited points, the relevance of such a study is its originality: being the first to focalize on the effect of H. pylori infection on the incidence of type 2 diabetes.
Thus, the reliability and relevance categorization of a study should never be based on merely counting the number of fulfilled criteria [48, 49].
Multiple evaluation methods are available to risk assessors [6, 21 27]; however, most focus exclusively on the evaluation of reliability with the exception of those provided by Ågerstrand et al. [15] and Beronius et al. [24], while the equally important relevance aspects of a study are not considered.
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