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We investigated the regulatory roles of a high-confidence and reproducible set of 69 trait-relevant lincRNAs (TR-lincRNAs) in human lymphoblastoid cells whose biological relevance is supported by their evolutionary conservation during recent human history and genetic interactions with other trait-associated loci.

Pathophysiological relevance is supported by data demonstrating that early and high circulating levels of IL-6 are associated with increased mortality [ 9].

Nevertheless, we succeeded in isolating thirteen of the 50 most frequent TCCs in L-III, and their relevance is supported by the presence of four of them in another brain region.

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An upregulation of PON2 and its relevance are supported by recent studies that found high PON2 levels in association with poor prognosis in cohorts of pediatric ALL or with imatinib resistance in CML patients.

To the extent that the WBC relevance hypothesis is supported we explore whether the informativeness of WBC gene expression is broad or varies by specific functional categories.

The relevance of OBFC1 is supported by the finding of Maubaret et al. [70], where an OBFC1 haplotype (rs10786775G and rs11591710C) was associated with lower risk of coronary heart disease.

The physiological relevance of serotonylation is supported by the abolishment of 5-HT-induced aortic contraction by cystamine in a concentration-dependent manner (figure 5B, top).

This effect is associated with enhanced growth of NPC cell lines and its relevance to NPC is supported by the frequent expression of IGF-1 in tumor biopsies.

The clinical relevance of EMD is supported by its long-term outcome stability in studies with 10 15 years of follow-up [ 10].

This decrease in the relevance of genotype is supported by a reduction of its effect size throughout development: ηAG = 0·30, ηPB = 0·13 and ηSS = 0·12.

The clinical relevance of p66Shc is supported by the notion that p66Shc gene expression is increased in mononuclear cells obtained from patients with type 2 diabetes and coronary artery disease [ 68].

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