A clinical relevance is indicated by the fact that both miRNAs are lost in the highly aggressive basal type of breast cancer, which, in contrast to the luminal and ductal invasive type, is poorly differentiated, shows no expression of oestrogen and progesterone receptors, and has a worse clinical prognosis (Sempere et al, 2007).
Moreover, synergistic tau- α-syn interactions of pathologic relevance are indicated by experimental findings both in vitro and in animal models, including evidence of mutually enhanced protein fibrillation.
No findings of clinical relevance were indicated by electrocardiogram (ECG), physical examination, vital signs or laboratory investigations as assessed on the day before first dosing and 9 days after the last dose.
That the effects we observed in vitro are also of relevance in vivo is indicated by the fact that the metacestode stage, which grows continuously within the host liver, is not producing intrinsic insulin-like peptides for the main receptor of this stage, EmIR1, thus leaving host-derived insulin as the only relevant hormone of this class at the site of infection.
Its relevance for SaaS adoption is indicated by previous research [23].
The relevance of the latter is indicated by persistently high savings rates even in "developed" Chinese societies such as Hong Kong, Singapore and Taiwan.
During the past two decades, a great number of studies have been published purporting to have identified gene variants that predispose to obesity [as summarized in (9)].The credibility and relevance of these studies is indicated by the success of replication attempts within and beyond the geographic and ethnic groups from which the original reports hailed.
The biological relevance of these predictions is indicated by the increased proportion of biological changes explained through primary and secondary miRNA function when considering only those genes modulated across multiple conditions and cell types, thereby supporting the adoption of a broad approach in biological modelling of miRNA function.
The credibility and relevance of these genetic association studies is indicated by the success of replication attempts in diverse ethnic groups.
bThe point total, where every score of 1st is 5 points, 2nd is 4 points, etc. cThe 'Relevance Class' resulting from the Points is indicated as: I: 0 points, II: 1 10 points, III: 11 20 points, IV: ≥21 points.
Importantly, physiological relevance is also indicated by the in vivo nocifensive behavior and clear withdrawal response elicited by light stimulation of KRT-ChR2 mice.
