Relevance indicates that the biomarker will impart biological data to risk assessors that will allow them to make a scientifically informed decision of a potential public health concern from exposure to the chemical.
The purpose of the meta-analysis is two-fold: on the one hand it identifies a group of genes with overall disease relevance indicating common, tissue-independent processes related to the disease; on the other hand it identifies genes showing specific alterations with respect to a single study.
Oncolytic virotherapy is a treatment approach with increasing clinical relevance, as indicated by the marked survival benefit seen in animal models and its current exploration in human patients with cancer.
The clinicopathological relevance analysis indicated that Linc00974 might participate in HCC metastasis.
Moreover, synergistic tau- α-syn interactions of pathologic relevance are indicated by experimental findings both in vitro and in animal models, including evidence of mutually enhanced protein fibrillation.
Studies such as [ 5] present the factors related to the patient, operator, tooth, cavity size, and materials, although it is not possible to determine the level of relevance as indicated in the study [ 5].
No findings of clinical relevance were indicated by electrocardiogram (ECG), physical examination, vital signs or laboratory investigations as assessed on the day before first dosing and 9 days after the last dose.
Although the hyperpolarization result has become more accepted in recent literature, this result may not have physiological relevance as indicated by the depolarization of neurons cultured in 2% oxygen, which is similar to the neuron's in vivo environment.
Of these, 5564 (61%) were clinically relevant, 290 (3%) indicated former relevance, 1822 (20%) were not clinically relevant, and relevance was unknown for 1495 (16%).
