Included in this group of drugs, glucosamine has demonstrated its efficacy and clinical relevance in several clinical trials [ 1- 3] and animal models [ 4, 5] helping to restore the proteoglycan matrix of the articular cartilage, to protect damaged cartilage from metabolic impairment [ 6] and having a mild anti-inflammatory activity [ 4].
Previously, both the downregulation of HLA class I, presence of Tregs and HLA-E and -G expressions have been shown to be of clinical relevance in several types of cancers (Curiel et al, 2004; Hiraoka et al, 2006; Gao et al, 2007; de Kruijf et al, 2010b).
Finally, given the relevance of TNF in several pathophysiological states such as cancer and aging [51], [52], and its connection with the deregulation of the Notch signaling pathway implicated in these diseases [26], [53], [54], suggests that the significance of TNF regulation of Notch-1 may extend to tissues other than skeletal muscle.
Collectively these studies indicated the relevance of ABCG2 in several human malignancies and its association with drug resistance and cells differentiation.
The evidence for relevance is given in several ways: (a) the literature investigation at the start of this section revealed that most genes we found are related to pluripotency, even though most of them are not well-known pluripotency genes.
Although the relevance of mutations in several DNA repair genes (BRCA1, BRCA2, TP53, PTEN, PALB2, BRIP1) in breast cancer susceptibility have been well established, the association of variants in other genes, potentially accounting for the remaining familial clustering, is not well defined.
SPECT-CT has an increasing relevance in diagnosis of several medical specialties [ 4, 7].
The same upstream analysis suggests potential relevance in CIMP of several members of the sonic hedgehog pathway, which is consistent with tissue-specific patterns of aberrant CGI methylation.
In addition to their prognostic relevance in primary disease, several proteases have been shown to be positive or negative predictive factors for the efficacy of adjuvant systemic endocrine therapy or chemotherapy in patients with breast cancer.
Ontology is no longer a mere research topic, but its relevance has been recognized in several practical fields.
Its relevance as a mediator in several pathologic states and the aging process together with its transient character and low steady-state concentration, motivated the development of a variety of techniques for its unambiguous detection and estimation.
