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Comparative transcript profiling allowed the identification of differentially expressed genes with potential relevance in regulating the fruit metabolism and phenolic content during ripening.
It is accepted that the interactions of this membrane-bound peptidase with other transmembrane proteins and/or the extracellular matrix (ECM) may have similar or even more relevance in regulating cells than cleaving bioactive peptides [ 7].
To further test Bursicon's functional relevance in regulating ISC proliferation, we overexpressed burs in the enteroendocrine cells (voilà ts >burs; Figures S3E and S3G) and examined the effect of this manipulation on ISC proliferation.
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Results from an independent screen using an RNAi library against human DUB family members also indicated the physiological relevance of USP15 in regulating TGF-β superfamily function.
These findings demonstrate that SCs are synergistically activated by PPR signaling and CD40L, and attest to the relevance of CD40L/CD40 signaling in regulating the SC response to PTH.
Altogether these results confirm the in vivo relevance of these receptors in regulating the survival of MNs.
The functional relevance of the histidine in regulating small ligand binding has been a central feature of studies of both Hbs and Mbs.
Although further studies are needed to ascertain the direct functional relevance of IL-18 in regulating immune responses in SS, our data suggest an important contribution of this cytokine to the modulation of immune inflammatory pathways in SS.
Hence, future work should shed light on the functional relevance of these intronic SNPs in regulating cancer risk.
Whether the endogenous human PPARα-tr has a specific physiological significance in regulating metabolic processes as well as its relevance for hepatocarcinogenesis remained unclear.
In relevance to this study, miRNAs have been demonstrated to be essential in regulating atrial excitability and can be involved, directly or indirectly, in increased atrial arrhythmogenicity and AF (reviewed in [ 11– 11]).
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