Exact(5)
Cerebral gray matter (GM) atrophy has clinical relevance in multiple sclerosis (MS).
As SOX11 has shown to have a functional role and prognostic relevance in multiple cancer entities, we further investigated the potential to re-express SOX11 using epigenetic drugs.
Together, these results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in Multiple Sclerosis.
The search for the genes of relevance in multiple sclerosis has reasonably been likened to searching for a handful of rather small needles in a very large haystack (Hensiek et al., 2003 b ).
SNP rs4253238 is also a prevalent SNP (MAF=0.496; HapMap CEU population) making it a potential widespread regulator of scuPAR with relevance in multiple human conditions, although further studies are needed to identify the SNPs in the rs4253238 LD block that are functionally relevant.
Similar(55)
Integrating knowledge about the different approaches to lactation and breastfeeding in European NICUs could improve the relevance of recommendations in multiple cultural settings.
Of relevance is the observation in multiple myeloma (an osteolytic disease) patients, decreased osteocalcin levels, as reported here, was related to reduction in skeletal related events [28].
Further analysis by fluorescent in-situ hybridization with larger cohort may provide more impactful insight on the clinical relevance of MALAT1 expression in multiple myeloma.
This investigation is of main relevance in the design of multiple models controllers for choosing the number of linear models and their distribution in the parameter space.
The use of multiple biomarkers has the theoretical attraction of improving both sensitivity and specificity in the diagnosis of different cardiac disorders, with particular relevance in the ICU where multiple confounding factors exist.
The relevance of TNF has been demonstrated in multiple animal models.
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Justyna Jupowicz-Kozak
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