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Although significant differences were observed in fiber diameter between controls and Actb-MNsKO mice at both 6 and 12 months (Figure 5C D, G H), the small differences of approximately 2 µm are unlikely to be of physiological relevance, consistent with no significant differences observed in muscle performance at either 6 or 12 months in Actb-MNsKO mice (Figure 4A D).
However, the analysis of this group of genes did not reveal any biological relevance, consistent with the idea that the source of the variation was primarily technical and associated with the differences in the protocols' steps (see Additional file 2: Table S2).
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This may be of biological relevance and would be consistent with the structures of PDC109 we obtain via MD, being compatible with a hypothetical unbound monomer and membrane bound dimer configurations.
Students' general awareness of the relevance of anatomy is consistent with results reported by Moxham & Plaisant [ 31].
This evidence of dopamine modulation of activities sensitive to the behavioural relevance of cues is consistent with other evidence that dopamine enhances the processing of salient environmental signals, thereby assisting appropriate responses (Nicola et al., 2000).
Thus, our results with imipramine are probably not of therapeutic relevance but are nonetheless consistent with the report that 50 μM imipramine reduces the Vmax for oxidation of allopregnanolone by recombinant rat type 1 3α-HSD in vitro (Griffin and Mellon, 1999).
In contrast, consistent with their relevance in endometrial receptivity [12], CD15, L-selectin ligands, were detected on the cell surface of both primary EEC and in a small percentage of cells from the receptive RL95-2 line, but not on HEC-1-A cells.
Consistent with the relevance of the BPH/2J strain to the morning BP surge in human hypertension, the present study has identified the genes for aldehyde dehydrogenase family 1 subfamily A2 (andh1a2) and solute carrier family 8 (sodium/calcium exchanger) member 1 (Slc8a1), which are two genes identified in genome-wide association studies of hypertension [22], [23].
Data for our other cell lines were consistent with their relevance as models of primary cases associated with MMR (D283Med) and MGMT (D425Med) deficiency.
Statistical analyses further confirmed that this enrichment of YY1 binding motifs is consistent with functional relevance and has likely been driven by unknown selection pressure at the DNA level.
Our study found a relatively few high quality research syntheses on health systems interventions of relevance to LMICs, which is consistent with other authors' assertions about the paucity of health systems research[ 18].
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