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Moreover, the relevance category C4 (=Not assignable) was added to the final CRED evaluation method.
(ii) Relationship between the number of fulfilled CRED criteria and reliability or relevance categories: The mean number of CRED evaluation criteria fulfilled by a study was associated with the assigned reliability or relevance category (Table 3 and SI part C Fig C2).
Twenty-one aberrations corresponded to the Uncertain Relevance category, four cytogenetically balanced rearrangements and 16 copy number alterations, three of them in malformed fetuses.
The 'Relevance' category refers to the attributes of genome projects that provide information about the wide area of research a particular genome is a part of, such as Antibiotic production, Agricultural, etc. [ 30].
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b Study- specific relevance categories assigned using the Klimisch and CRED evaluation methods for studies A H.
To determine the relationship between the number of fulfilled CRED criteria and assigned reliability or relevance categories, the number of fulfilled criteria was recorded for each study evaluation.
Reliability and relevance categories assigned to each study were tested for significant differences between evaluation methods using the exact (permutation) version of the Chi-square test in R [37].
Two main aspects were investigated to compare the practicality of the two evaluation methods: (i) the time required to evaluate a study and (ii) the relationship between the number of fulfilled CRED criteria and assignment of reliability or relevance categories as an indication of the usefulness of the selected criteria for assigning categories.
To determine whether one of the tested evaluation methods would produce more consistent results than the other method, the percentage of evaluations in each conclusive reliability (R1 R3) or relevance (C1 C3) category was calculated for each study.
Finally, the relevance of categories for metaphysical issues became crucial, so that it was in the context of metaphysical works, such as Aquinas' Commentary on Aristotle's "Metaphysics" and Suárez's Metaphysical Disputations that we find some of the richest discussions.
These functional advantages in visual identification of animals compared to other categories could result from a segregated recognition mechanism, which evolved due to the high biological relevance of this category.
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