In particular release studies demonstrated that flurbiprofen is released by the emulgels in a controlled manner, the drug release efficacy within the first 100 min was comprised between 50 and 80% of the total amount of the drug.
Imipenem-loaded ALBCs showed a significantly worse antibiotic release efficacy as compared with ALBCs with other preparations.
We used analysis of variance (ANOVA) to determine the statistical difference in the ultimate compression force and antibiotic release efficacy between cements with different preparation.
During the 14-day study period, imipenem-loaded ALBCs showed a significantly worse cumulative antibiotic release efficacy compared with the other tested antibiotics (all p < 0.001) (Table II).
The samples were further investigated for their drug loading and release efficacy through RF activation of embedded MNS, which may stimulate triggered behavior and hence release the loaded therapeutics.
An attractive option to increase the photon-to-heat conversion efficiency, and hence conserve the same release efficacy at lower laser powers, would be to exploit water absorption bands with greater absorptivity (i.e., 1200, 1450, and 1950 nm).
Therefore, in addition to the spectrum of antibiotic loaded in the ALBC, the release efficacy of antibiotics from the bone cement and the minimal inhibitory concentrations of antibiotic are all the critical factors which determine antibacterial activities of ALBCs.
To demonstrate the siRNA release efficacy of this polymer in a reducing environment comparable to the cytosol, particles were incubated in a solution of 5 mM glutathione for 15 min prior to electrophoresis.
DOI: http://dx.doi.org/10.7554/eLife.04057.003 Exploiting the technical advantages of this synapse (including ideal voltage-clamp conditions conveyed by perisomatic synapse location, presynaptic accessibility due to short axon trajectories, and optimal signal-to-noise ratio because of large quantal size), we first examined the [Ca2+]o dependence of release efficacy.
Although GABA is constantly released, the efficacy of the receptor-mediated inhibitory currents (Cl−) and membrane hyperpolarization are enhanced, due to the increased GABAAR numbers at the cell surface.
