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Lentivirus pseudotyped with the modified envelopes bound to fibrinogen in a factor XIII dose dependent manner and was released upon plasmin treatment.
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During the coagulation process the conversion of prothrombin to thrombin and its subsequent activity leads to cleavage of fibrinogen to form fibrin. Fibrin deposits in the tumor microenvironment are the store of thrombin that is released upon degradation of fibrin by plasmin [ 133].
Both prodrugs showed to be stable in buffer solution and both parent drugs were released upon incubation in the presence of plasmin.
Furthermore, payload may be released upon degradation into circulating blood.
They will be released upon publication.
They will be released upon publication of the paper.
The inhibition was released upon addition of 5 mM glutamate).
Tourniquet occlusion was released upon completion of the washout.
Replicated phages released upon bacterial lysis were purified.
Another pro-apoptotic factor released upon MMP is SMAC/DIABLO.
Type I IFNs are cytokines released upon pathogen infection.
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