N-terminally palmitoylated HH releases the repression of Patched to the oncoprotein smoothened (SMO); however, the mechanism by which HH recognizes Patched is unclear.
Progression through the S phase is governed by the phosphorylation of Rb, which releases the repression of E2F target genes allowing transcription of S phase genes [38].
In resin-fed or FXR-null mice, the diminished Fgf15 signal releases the repression on Cyp7a1, leading to higher transcription of Cyp7a1 in livers.
In response to stress, such as drought, the binding of ABA to the PYR/PYL/RCAR/clade A PP2C complex releases the repression of ABA-activated SnRK2s to phosphorylate their substrates [24], [26] [28].
40, 41 Clearly, deletion of PXR releases the repression (de-repression) allowing for spontaneous induction of UGT1A1 gene expression.
Another words, the pseudogene may act as a 'miRNA decoy' to release the repression of its cognate gene.
CDKs phosphorylate the Rb family of proteins, which are negative regulators of E2F transcription factors and, as a consequence, release the repression of E2F-target cell cycle genes.
In cells, the pro-inflammatory cytokines release the repression of the nuclear receptor corepressor and subsequently also NF-κB, c-Jun N-terminal kinase (JNK) and phosphoinositide 3-kinase (PI3K) pathways.
The higher expression level in oxidative muscle and its repressive effect on PGC-1α promoter activity has puzzled us until we found that exercise can release the repression, especially in soleus muscle.
In this scenario, degradation of Ikaros and Aiolos would release the repression allowing expression of these repressors, which in turn will shut down the promoters of c-Myc and IRF4.
