Batch P1 achieved the bioadhesion up to 8 hours but the drug was not released within targeted 8 hours, so release retardant polymers, namely, HPMC K4M, K15M and K100M with different concentrations were incorporated in batches P4 to P9. Drug loading and in vitro drug release were varied as release retardant polymer was changed.
The order of the release positions was varied throughout the experiment.
Keeping the duration of the trapping phase constant (Ttrap = 2 μs), the duration of the release phase was varied from 0.02 to 0.9 μs; nine independent coarse-grained MD simulations were performed for each simulation condition.
The release medium's osmolality was varied using different sodium chloride concentrations, which was found to affect drug release rates.
When the time elapsed between the source release and the implementation of remediation was varied, it was found that, except for the longest elapsed time (50,000 days), a combination of partial source removal and plume remediation was most efficient.
The flow rate, surrounding condition and release duration were varied to study their influence on overall vapor cloud size i.e. diameter, height and explosive strength.
By changing the composition ratio of the two precursors, the phase transition temperature (lower critical solution temperature, LSCT) of the hydrogel scaffolds could also be adjusted to be or near the body temperature, so BMP release from microsphere hydrogel compounds could be accordingly controlled and the release period could be varied from 18 to more than 28 days.
The spill rates are varied to examine the importance of release characteristics.
Furthermore, the drug release profile of the silk biopolymer can be varied from immediate release to slow release over months (Wang et al, 2007), allowing for tailored drug administration schedule to suit individual clinical scenarios.
