After a few hours of prostaglandin release, the sensitivity of the pain receptors to noxious chemicals (e.g., histamine, bradykinin, acetylcholine, etc).
Sensitivity to pH allows one to capitalize on the drop in pH known to occur along the endosomal/lysosomal pathway for endocytosis to facilitate release, while sensitivity to a reducing environment could stimulate release in response to the reducing nature of cytosol [1].
However, it has been argued that extracellular glutamate and GABA, as measured by microdialysis, do not fulfill the classical criteria for exocytotic release (tetrodotoxin sensitivity, calcium-dependency).
Thus, one must additionally consider changes in neurotransmitter synthesis, release and sensitivity, in addition to synaptic contacts on GnRH neurons, to fully understand the mechanisms underlying reduced GnRH neuron activation on proestrus in middle-aged rats.
Accordingly, increased glutamate release and sensitivity of NMDA receptors caused striatal cell death.
Many micronutrients are involved in carbohydrate and/or glucose metabolism as well as with insulin release and sensitivity.
Cortisol can interfere in the normal regulation of blood glucose by altering the body's release and sensitivity to insulin (6).
Input: The scores (e.g. χ2 statistic or Hamming distance) of all M candidate SNPs, the number of SNPs, K, that we want to release, the sensitivity, s, of the score function, and the privacy budget ∈.
Input: The score of all M candidate SNPs, the number of SNPs, K, that we want to release, the sensitivity, s, of the score function, and the privacy budget E. Output: K SNPs.
Several studies have subsequently been performed with the objective to unravel intermediary phenotype of these loci to obtain a more detailed biological knowledge initially seeking to break the diabetes-related phenotype for each locus into the major components of type 2 diabetes pathogenesis being insulin release, insulin sensitivity, and obesity.
